Atherosclerosis is an inflammatory condition of the arterial wall that is characterized by localized lipid-rich deposits of atheroma (cholesterol-containing leisons) that mainly stay silent till they get big to inhibit blood circulation or till ulceration or erosion of their lesion leads to obstruction or embolization of the affected vessel. Tasigna use has been linked to severe Tasigna atherosclerosis and peripheral arterial disease.
Atherosclerosis is a condition that starts early in life mostly among individuals that are at elevated risk (e.g. cigarette smokers, familial hyperlipidemia or hypertension). However, the symptoms usually become evident from the sixth, seventh or eighth decade.
Atherosclerosis may pose as coronary heart disease (angina, MI, departure), neurological (stroke and TIA) or peripheral vascular disease (intermittent claudication and limb ischaemia). These circumstances may frequently ensue.
The symptoms of atherosclerosis can pose as moderate or severe forms.
A. Stable polyunsaturated fats (premature lesions) remains asymptomatic until they get large enough to block blood circulation.
B. In complex atherosclerosis ulceration or erosion happens to result in partial or complete occlusion of the vessel that is affected. It's the frequent mechanism which underlies a number of the acute manifestations of cardiovascular disease (e.g lower limb ischemia, myocardial infarction, and stroke).
The quantity and sophistication of arterial lesions grow with age and also with specific risk factors but the speed of development of human lesions is changeable. Some might develop the symptoms from a young age and some could even not create the symptoms in any way.